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Cover of Pathogenic

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Games like Pathogenic

2026PC, Steam Deck verified93 % positive9.99 €

A roguelike shooter where you play as a pathogen invading the human body, evolving your parasite with collected organelles. You fight the host's immune system across procedurally generated microscopic environments.

  • Runs that play out differently every time
  • Build variety
  • Loot and gear
  • Shooting and gunplay
＋ Combine with my games

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More in these topics: Roguelikes and roguelites Action games Hidden gems Indie games

In short: Games like Pathogenic

Each of these 10 games shares something of what makes Pathogenic special. The reasons are listed right on each game.

Similar in what way?

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Not for me Exclude horror, turn-based combat, pixel art …

Games where this is clearly part of it are left out, no matter how well the rest fits.

Horror Turn-based combat High difficulty Roguelike runs Shooter Pixel art Grind Survival PvP Open world Card game

10 games with a similar feel, sorted by match · How is this calculated?

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Best match

Gunfire Reborn

98 %Match

2021USK 12PC, PlayStation, Xbox, Nintendo Switch, Steam Deck verified93 % positive16.79 €

Fits your focus: Systems like Pathogenic.

A fast-paced roguelite first-person shooter where you fight through procedurally generated levels alone or with up to three friends, crafting varied builds from heroes, weapons and upgrades.

Where to buy

* Affiliate link. Prices are synced regularly and may have changed in the shop since.

Similar games →

Deep Rock Galactic: Survivor

  • Systems like Pathogenic

A survivor-like set in the Deep Rock universe where a lone dwarf auto-shoots through alien swarms while carving through destructible rock for minerals. Synergizing weapon upgrades and persistent unlocks deliver that one-more-run pull.

Soul Knight

  • Systems like Pathogenic

A fast pixel-art roguelike shooter where you blast through randomly generated dungeons, collect wacky weapons and dodge bullets. Simple controls and a large roster of heroes make it ideal for quick runs, including co-op.

Risk of Rain 2

  • Systems like Pathogenic

A frantic 3D roguelike shooter where random items stack into absurdly powerful builds while the difficulty relentlessly ramps up over time. Fight across a hostile alien planet solo or with up to three friends in co-op.

Brotato

  • Systems like Pathogenic

A snappy arena roguelite where a potato wields up to six weapons at once against waves of aliens. Short runs plus dozens of quirky characters and item synergies make for huge replay value.

The Binding of Isaac

  • Systems like Pathogenic

A grotesque twin-stick roguelike set in randomly generated basements, where countless bizarre items transform Isaac in wildly different ways each run. Dark, religiously tinged humor meets huge replayability and a wealth of secrets to unlock.

Roboquest

  • Systems like Pathogenic

A fast, colorful roguelite FPS where you play a rebooted robot Guardian and blast hordes of machines through shifting levels, solo or in co-op. Fluid movement, varied weapons and classes make every run feel different.

Risk of Rain

  • Systems like Pathogenic

A 2D pixel-art roguelike platformer where you grow stronger on an alien planet by stacking random items while the difficulty keeps climbing over time. Playable solo or with up to three friends, each run feels different thanks to chaotic item combinations.

Risk of Rain Returns

  • Systems like Pathogenic

A fast 2D roguelike action game where you stack items to become absurdly powerful while the difficulty keeps climbing with time. The remake adds new survivors, abilities and content, and co-op makes the chaos even better.

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